APS-MEA is a term that refers to a concept from the imaging field applied to microelectrode arrays (MEA). APS stands for Active Pixel Sensor and was originally developed for CMOS-based image sensors. Commercially available MEA-systems record a network of a large number of neurons with only a few tens of electrodes. Therefore, the measured activity is largely undersampled and represents only a very coarse view of the actual network.
With our new high-density MEA platform, we refer to it as APS-MEA-platform, we increase the number of recording electrodes by almost a two orders of magnitude for the same culture area. Therefore, the signals we obtain give a much more detailed view of the physiological activity in the network.
We implemented a complete high-density platform featuring 4096 electrodes on an active area of 7 mm2, including
- the high-density microelectrode array (APS-MEA)
- a high-speed hardware for the electronic acquisition
- data analysis and visualization software (Windows XP 32bit/64bit).
Our team of experts has a multidisciplinary background. Our key competences are:
- Electronic System Design
- Microelectronics
- Bioengineering
- Neuroelectrophysiology
- Microfabrication
- Programming
- Signal Processing
- Real-time Systems
Furthermore, we have access to a broad network of people from Cell and Molecular Biology, Neurophysiology, Neural Engineering and Neural Computation.